Alterations in 5-HT1B receptor function by p11 in depression-like states.
نویسندگان
چکیده
The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
منابع مشابه
Supporting Online Material for Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States
متن کامل
Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation.
p11 (S100A10), a member of a large family of S100 proteins, interacts with serotonin receptor 1B (5-HTR1B), modulates 5-HT1B receptor signal transduction, and is required for antidepressant responses to activation of this receptor. In the current study, we investigated the specificity of the interaction between 5-HTR1B and p11 by screening brain-expressed S100 proteins against serotonin and nor...
متن کاملScience 6 January 2006:Vol
Depression is a mood continuum, ranging from normal but temporary "bad days" to a completely disabling clinical condition characterized by overwhelming despair that lasts for weeks or months. A popular theory is that a breakdown in signaling by the brain neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) is critically involved in the symptoms of clinical depression, but the nature of this d...
متن کاملPharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.
Serotonin (5-HT) plays a central role in the integrity of different brain functions. The 5-HT homeostasis is regulated by many factors, including serotonin transporter (SERT), monoamine oxidase enzyme (MAO), and several 5-HT receptors, including the 5-HT1B. There is little knowledge how the dynamics of this system is affected by the amyloid-β (Aβ) burden of Alzheimer's disease (AD) pathology. S...
متن کاملP139: Role of Dopamine Receptor D3 in Depression and Anxiety
Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Science
دوره 311 5757 شماره
صفحات -
تاریخ انتشار 2006